x64dbg with plugins like ScyllaHide to mask debugger presence.
Running a Themida 3.x binary inside a standard debugger will immediately trigger a crash or an error message. Analysts use heavily modified debugging environments: Themida 3.x Unpacker
At the core of Themida is the SecureEngine® framework. This engine runs at the highest privilege levels possible, frequently employing kernel-mode drivers to monitor the operating system. It detects debugging tools, hardware breakpoints, virtualization software, and API hooking attempts before the actual protected application even initializes. 2. Code Virtualization (Virtual Machines) x64dbg with plugins like ScyllaHide to mask debugger